Figure 1
Localization of the 16 identified missense point mutations in JAK1 and JAK3. The figure represents the predicted 3-dimensional structure of kinase and pseudo-kinase domains of JAK1 and JAK3 based on the recent TYK2 crystal structure.29 Molecular images were obtained with the PyMOL molecular visualization system. The pseudo-kinase domain is shown in light blue for JAK1 and green for JAK3. The adjacent kinase domain is shown in violet for JAK1 and pink for JAK3. The αC helix is shown in beige and activation loop in red. Mutated residues are indicated with orange balls.
