Mode of action of lactadherin in alleviating the consequences of TBI. TBI results in the release of brain-derived microvesicles, which activate coagulation and result in a consumption coagulopathy. Both systemic thrombosis and secondary brain hemorrhage as a result of exhaustion of platelets and coagulation factors result in poor outcome. Lactadherin binds to brain-derived microvesicles, which are subsequently cleared by phagocytes. Professional illustration by Patrick Lane, ScEYEnce Studios.