The level of expression of the patient’s mismatched HLA-C allotype associates with transplant outcome. (A) ORs of grades III to IV acute GVHD and (B) HRs of nonrelapse mortality for each mismatched HLA-C allotype in the patient is shown relative to C*07. The expression of the patient’s mismatched allotype was defined by its MFI as determined previously.22 The size of each circle is proportional to the number of patients with the indicated allotype. The least-squares line shown is weighted by the number of observations at each expression level.