Long-term outcomes by clinical response to 1 week of treatment in all patients. Patients were divided into 2 groups based on response to treatment: early treatment sensitive (ETS; dotted line) and early treatment resistant (ETR; solid line). (A) Test cohort (n = 236). Twelve-month cumulative incidence of NRM (ETS 20% vs ETR 42%, P < .001) and OS (ETS 63% vs ETR 51%, P = .02) and proportion of patients resistant to treatment at week 4 (ETS 24% vs ETR 57%, P < .001). (B) Validation cohort 1 (n = 142). Twelve-month cumulative incidence of NRM (ETS 13% vs ETR 41%, P < .001) and OS (ETS 72% vs ETR 50%, P = .004) and proportion of patients resistant to treatment at week 4 (ETS 39% vs ETR 59%, P = .03). (C) Validation cohort 2 (n = 129). Twelve-month cumulative incidence of NRM (ETS 8% vs ETR 31%, P = .001) and OS (ETS 87% vs ETR 60%, P < .001) and proportion of patients resistant to treatment at week 4 (ETS 11% vs ETR 41%, P < .001).