Long-term outcomes by biomarker probabilities in early treatment sensitive patients. Early treatment–sensitive patients were subdivided based on biomarker probabilities into low and high groups. (A) Test cohort of patients (n = 114). Twelve-month cumulative incidence of NRM (low 11% vs high 41%, P < .001) and OS (low 70% vs high 47%, P = .004) and proportion of patients resistant to treatment at week 4 (low 18% vs high 38%, P = .06). (B) Validation cohort 1 (n = 62). Twelve-month cumulative incidence of NRM (low 6% vs high 33%, P = .005) and OS (low 79% vs high 53%, P = .03) and proportion of patients resistant to treatment at week 4 (low 30% vs high 67%, P = .03). (C) Validation cohort 2 (n = 61). Twelve-month cumulative incidence of NRM (low 6% vs high 20%, P = .46) and OS (low 88% vs high 80%, P = .80) and proportion of patients resistant to treatment at week 4 (low 8% vs high 28%, P = .18).