Figure 7.
Figure 7. How is full reduction of KO to KH2 accomplished during warfarin therapy? (A) VKORC1 normally performs 2 reactions to generate the KH2 cofactor required for VKD protein carboxylation. (B) During warfarin therapy, a warfarin-resistant quinone reductase may cooperate with VKORC1 to produce KH2.

How is full reduction of KO to KH2accomplished during warfarin therapy? (A) VKORC1 normally performs 2 reactions to generate the KH2 cofactor required for VKD protein carboxylation. (B) During warfarin therapy, a warfarin-resistant quinone reductase may cooperate with VKORC1 to produce KH2.

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