Timeline and clinical manifestations of the disease in the patients. (A) Timeline of clinical presentation of the disease in patients 1 and 2. (B) Family tree shows the carrier of the XIAP mutation (half-shaded) and the patients (shaded). The western immunoblot demonstrates a dramatic reduction in mutant XIAP expression in patients 1 to 3. (C) Clinical manifestation of XLP2 in patients 1 to 3. CAR-T, chimeric antigen receptor T cell; Con, control; IVIG, IV immunoglobulin; Pt., patient; y.o., years old.