DYD CA effectively clears circulating CD38-bispecific protein from the bloodstream. Athymic nude mice (n = 3-5 per group) were injected at −24 hours with 1.4 nM CD38-bispecific protein (028-C825), then at −1 hour with 5 µg of CA, and at 0 hours with ⁹⁰Y-DOTA–biotin. Controls received no CA. Percent ID per gram (%ID/g) was determined from retro-orbital venous samples taken at serial time points starting 5 minutes after the ⁹⁰Y-DOTA–biotin injection. Error bars = 1 standard error of the mean (SEM).