Figure 1.
OS and immune reconstitution after CBT in patients with refractory aplastic anemia. (A) OS after CBT in patients with refractory aplastic anemia. Estimated 1-year OS of 88.5% (95% CI, 77-100) and 2-year OS of 84% (95% CI, 71-100 are represented, Kaplan-Meier curve). OS was similar between patients who received 1 or 2 unrelated CB units (as was the case for cumulative incidences of engraftment, aGVHD and cGVHD, and infections). (B) Reconstitution of T-, B-, and natural killer (NK)-cell subsets. All patients were systematically monitored posttransplantation for immune reconstitution at days +45 and +60, and months +3, +6, +12, and +24. T lymphocytes, CD4, CD8, B, NK lymphocytes were prospectively measured. For each time point, 25th to 75th percentiles are shown, along with the median.