EV exchange by DLBCL cell lines and uptake by normal tonsillar cells. (A) Positive SYTO RNA fluorescent stain of supernatant from recipient OCI-Ly3 cells previously incubated with EVs from stained donor OCI-Ly1 cells (left panel) and positive stain for the general exosome marker CD63 (right panel), indicating uptake of RNAs from stained OCI-Ly1 donor cells. (B) Control negative SYTO RNA fluorescent staining of supernatant from recipient OCI-Ly3 cells incubated with EVs of unstained OCI-Ly1 donor cells (left panel), and positive staining for CD63 (right panel). (C) Positive SYTO RNA fluorescent stain in recipient normal tonsillar lymphocytes incubated with EVs isolated from previously stained donor OCI-Ly1 (left panel) or HBL1 (right panel).