Platelet GPVI, but not CLEC2, supports local host defense during pneumonia-derived sepsis. Mice were injected with JAQ1 (5 days prior to infection), INU-1 (5 and 2 days prior to infection), or IgG control antibody, infected with K pneumoniae via the airways, and euthanized 12, 36, or 42 hours after infection. Data are number of CFUs in the body site indicated for JAQ1 (A-D) and INU-1 (E-H). Data are represented as box and whisker plots of 8 mice per group at each time point. *P < .05, **P < .005 vs IgG control.