GPVI^−/− mice also have impaired immunity during gram-negative pneumonia–derived sepsis. Control or GPVI^−/− mice were infected with K pneumoniae via the airways and sacrificed 36 hours after infection. (A-D) Bacterial loads for organs indicated. (E) Lung pathology score. (F) Liver pathology scores. (G-I) Levels of aspartate aminotransferase (AST) (G), alanine aminotransferase (ALT) (H), and lactate dehydrogenase (LDH) (I). (J) Bleeding score in the lung. (K) Hemoglobin levels in the lung. Data are presented as box and whisker plots of 8 mice per group. *P < .05 and **P < .005 vs control.