Generation of Srsf2 P95H conditional knockin mice. (A) Schematic representation of the targeted Srsf2 allele. (B) Sanger sequencing of polymerase chain reaction products of cDNA of the BM cells from Vav1-Cre^+/−Srsf2^floxP95H/WT mice (left), and RNA-seq of KSL cells of Vav1-Cre^+/−Srsf2^WT/WT and Vav1-Cre^+/−Srsf2^floxP95H/WT mice (right). (C) Western blot analysis of the expression of Srsf2 in the BM-derived nucleated cells of Vav1-Cre^+/−Srsf2^WT/WT and Vav1-Cre^+/−Srsf2^floxP95H/WT mice. FRT, flippase recognition target.