Comparisons of misspliced genes in Srsf2-mutated cells between different mouse models and human cells. (A) Comparisons of misspliced genes in KSL and MP cells from Srsf2 mutant transplanted mice in the current study and those from Mx1-Cre–mediated Srsf2 mutant mice (Kim et al12 ). Genes registered in the Cancer Gene Census are shown in red. Genes implicated in the pathogenesis of myeloid malignancies are marked with asterisks. (B) Comparisons of differentially spliced genes in KSL and MP cells from Srsf2 mutant transplanted mice in the present study, SRSF2-mutated primary acute myeloid leukemia (AML) and CMML samples (Kim et al12 ), and K562 cell line transduced with mutant SRSF2 (Zhang et al13 ). Genes registered in the Cancer Gene Census are shown in red. Genes implicated in the pathogenesis of myeloid malignancies are marked with asterisks. (C) Pie chart showing the number of promoted/repressed CEs in both KSL and MP cells from Srsf2 mutant transplanted mice but not in SRSF2 mutant human samples, with or without corresponding transcripts of the human orthologs. For those CEs who had human corresponding transcripts, the frequency of SSNG motifs (counts per kilobase) was compared between mice and humans.
