Unexpected dynamic range revealed through the quantitative assessment of the platelet lipidome. (A) Violin plot displaying the dynamic range of different lipid classes in a resting platelet. Each column assembles all of the quantified lipid species for 1 class. (B) Dynamic range of identified and quantified lipids species, covering 7 orders of magnitude in both human and mouse. (C) Fifteen lipids contribute 70% of the absolute lipid membrane mass of a resting platelet. (D) Correlation of presented mouse lipidome and human lipidome based on literature (supplemental Table 2) with R2 = 0.9888. (E) Quantitative comparison of the mouse and human lipidome in resting platelets at the lipid species level with a color-coding at lipid class level. All data are combined from at least 3 independent experiments, and mean values are shown.
