ALCLs with DUSP22 rearrangements overexpress CTA genes. (A) Affymetrix microarray analysis of 31 ALCLs in the frozen discovery set shows that DUSP22-rearranged ALCLs have a unique set of overexpressed genes, including multiple CTA genes and other genes regulated by methylation such as HAND1. WHO, WHO subtype. (B) CTA genes are significantly enriched in cases with DUSP22 rearrangements by GSEA. (C) Analysis of FFPE RNAseq gene expression data from an independent set of 53 ALCLs validates the DUSP22 and ALK molecular signatures shown in A. DUSP22 cases clustered together significantly (P = .0014), as did ALK cases (P < .0001). (D) GSEA of FFPE RNAseq data validates the enrichment of CTA genes in cases with DUSP22 rearrangements.