Further reduction in human G6b-B expression exacerbates observed phenotype. (Ai) G6b^hu/hu mice were crossed with G6b^−/− mice to produce hemizygous (G6b^hu/−) mice. (Aii) Representative blots of mouse G6b-B (mG6b-B), human G6b-B (hG6b-B) and hG6b-A and (Aiii) quantification of hG6b-B expression in the indicated genotypes (n = 3). (B) Average aggregation and ATP release traces (Bi) and quantification of AUC (Bii,iii) investigating functional response of G6b^hu/− mouse washed platelets (2 × 10⁸/mL) in response to indicated agonists (n = 5-6; ***P < .001; *P < .05). All bar graphs presented as mean ± SEM.