Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes DVT. (A) Representative thrombi scanned by ultrasonography. Thrombus areas: top, 3.1 mm²; bottom, 11.6 mm². Bar, 1 mm. (B-C) Kinetics of thrombus development (frequency) and thrombus size (area) in mice of the indicated genotype, measured by ultrasonography at the indicated times after ligation. (D) Thrombus weight in the indicated genotype 24 hours after ligation. Each symbol represents an individual thrombus. Horizontal black bars represent median values. (E-F) Kinetics of thrombus development (frequency) and thrombus size (area) in mice with the indicated treatment, measured by ultrasonography at the indicated times after ligation. (G) Thrombus weight with the indicated treatment 24 hours after ligation. Each symbol represents an individual thrombus. Horizontal black bars represent median values. The data in panels B and E were taken from 10 to 18 mice in each group. The data in panels C and F represent the mean ± SEM from 3 to 14 mice in each group. *P < .05.