Preleukemic dynamics in patients who received additional chemotherapy after ASCT. Representation of (preleukemic) clonal evolution of patients UPN07 (A), UPN03 (B), UPN21 (C), and UPN19 (D). For figure details and abbreviations, see Figure 4 legends. For UPN03 (B), post-ASCT treatment with thalidomide* 200 mg/week, later reduced to 150 mg/week, thalidomide** 50 mg/week, later reduced to 100 mg/3 weeks. Aza, azacitidine; LOPP, chlorambucil, vincristine, procarbazine, and prednisone; LPP, chlorambucil, procarbazine, and prednisone; MM, multiple myeloma; r, relapsing disease; R, rituximab; RT, radiotherapy.