Mutational enrichment in CLL patients. (A) Mutational enrichment in TN CLL patients and R/R CLL patients. Red diamond represents logarithmic OD and bar represents 95% confidence interval (CI). Red asterisks indicate statistically significant differences; yellow asterisks indicate trends toward statistical significance. (B) Mutational enrichment in CLL patients with IGHV mutations and CLL patients without IGHV mutations. Red diamond represents logarithmic OD and bar represents 95% CI. Red asterisks indicate adjusted P value of <.05; yellow asterisks indicate adjusted P value of <.1.