Recommended first-line therapy for ENKL. Our recommended treatments are listed. There are no data to determine the best treatment among them. *HD-AHSCT is added if the NK-cell lymphoma prognostic index score is 2 or 3. ^†In case of SMILE chemotherapy. LN, lymph node; ly, lymphocyte; (m)SMILE, SMILE or modified SMILE; peg-asp, pegaspargase.