FVIIa inhibits LPS-induced leukocyte infiltration into lungs. WT C57 BL/6J (WT), EPCR-overexpressing (Tie2-EPCR) or EPCR-deficient mice were administered with FVIIa and LPS as described in Figure 4. The lung tissues were fixed, sectioned and stained with hematoxylin and eosin (A), neutrophil marker LY-6G (B) or monocyte/macrophage marker F4/80 (D). The images were captured at 40X magnification. The scale bar indicates 100 µm. The number of LY-6G- (C) and F4/80- positive (E) cells were counted at 3 randomly chosen areas covering the entire section from tissue sections prepared 3 animals in a group. Data are the Mean ± SEM. *P < .05; ***P < .001; ns, not statistically significant.