t(11;14) and t(4;14) translocations results in de novo SE formation in MM. (A) H3K27Ac signals in MM cells at the CCND1 (top) and FGFR3/MMSET loci (bottom). Translocations involving the IGH locus (on chr14) in individual MM samples are indicated on the right. The black bar and dashed box indicate the de novo SE's genomic position. (B) Illustration depicting the normal CCND1 and FGFR3/MMSET loci and the loci after juxtaposition of IGH SEs with accompanying de novo SE formation and transcription. (C) RNA-seq expression levels (average FPKM ± standard deviation) of CCND1, MMSET, and FGFR3 in MM with or without the indicated translocation. N/A, not applicable; w/o, without. ***P ≤ .001; ****P ≤ .0001.