Building blocks of the MM TF regulatory network differ from normal cells. (A) ATAC-seq (Tn5 integration sites) signals in the 1-kb region surrounding the MLLT3 promoter region in memB, PB, PC, and MM cells. TF footprints identified by DNase2TF in each sample are displayed below each respective track. Putative TF binding sites (TFBS) are displayed below tracks. (B) The 13 possible network motifs (3-node circuits) were identified in a global network built from TF binding (determined by TF footprints) in TF gene promoters for the cell type (indicated on the y-axis). Each row in the heat map indicates the level of conservation of the identified network motif in the second cell type (indicated on the x-axis). The percentages of maintained network motifs are indicated to the right of the heat map. Network motifs are organized from the least to the most interconnected motif (left to right or top to bottom).