Core TF regulatory network derived from data integration. (A) Transcriptional networks were built for individual MM samples based on SE-associated TF genes and their binding to SEs (called by footprinting) and promoter regions of SE-associated TF genes. (B) Individual networks are combined into a merged SE TF regulatory network with weighted edges. (C) Cytoscape visualization of the merged SE TF regulatory network originating from 8 individual MM cell lines. Based on the weights of all connections, TFs are organized from the center (high weight) to the periphery (low weight) of the network. The node size represents the number of degrees or connections to the SE-associated TF gene, whereas a weighted edge defines the regulatory relationship (arrows indicating regulation/binding) between TF genes. Expression levels (log₂ FPKM) of TF in the network are indicated by color.