Genomewide occupancy and functional knockdown of key TFs in MM cells. (A) Browser shots showing IRF4, FLI1, H3K27Ac, and H3K4me2 ChIP-seq in KMS12BM MM cells at the IRF4 (left) and PRDM1 loci (right). (B) Distribution of IRF4 and FLI1 ChIP-seq signals at SEs and TEs (defined by H3K27Ac). (C) Cooccupancy of IRF4 and FLI1 at SEs (% of SEs identified in KMS12BM). (D) Percentage of live cells in knockdown samples relative to scramble controls at indicated time points. Two independent experiments with 2 replicates of each were performed.