Pathways that are recurrently mutated in newly diagnosed cHL. In the heat map, rows correspond to genes and columns represent individual patients. Color coding is based on gene alteration status (gray, wild type; red, mutated). The heat map was manually clustered to emphasize mutational co-occurrence. On the right side is a schematic representation of the mutated pathways. Mutated genes are marked by an arrow, and the prevalence of mutations is reported. The following pathways are shown: NF-κB (A), PI3K/AKT (B), cytokine signaling (C), epigenetics (D), immune surveillance (E), and NOTCH signaling (F).