Kaplan-Meier survival curves for progression-free survival according to MRD status. (A) According to MRD status at the start of maintenance therapy. The median progression-free survival from the start of maintenance therapy was not reached among MRD⁻ patients, and was 29 months among MRD⁺ patients. (B) After 12 months of maintenance therapy. The median progression-free survival from the completion of maintenance therapy was not reached among MRD⁻ patients, and was 20 months among MRD⁺ patients. (C) Modified by the Simon-Makuch Method. The number of patients at risk in the MRD⁻ group was 0 at the beginning of follow-up because of the time-dependent nature of MRD. Prior to the start of maintenance therapy, all patients were included in the MRD⁺ group; patients who were found to be MRD⁻ on assessment during maintenance were switched to the MRD⁻ group. The median progression-free survival from randomization was not reached among MRD⁻ patients, and was 29 months among MRD⁺ patients.