A) Plot of response rate vs. dichotomized PKCβ2 IHC H score, assessing the inner 80% of the marker distribution. At each of the H scores within the inner 80% of cytoplasmic PKCβ2 range, the patient population is dichotomized into high and low expression groups. The response rate is calculated and plotted for each of these two groups. Regardless of the cutpoint chosen, the RR in the low expression group is higher than the RR in the high expression group and higher than the overall study RR. B) Plot of unadjusted p-value (transformed on the –log10 scale) vs. H score comparing high to low expression group in the logistic regression model. Adjusted p-value is based on the asymptotic distribution of the maximal chi square statistics (Miller and Siegmund. Biometrics.1982; 38:1011-1016), limiting the assessment on the inner 80% of marker values.