Adhesion molecule and chemokine receptor expression profiles of B-lymphocyte subsets and related lymphoid malignancies. Naive B lymphocytes coexpress L-selectin and α4β7, enabling them to migrate to the mucosa as well as to peripheral lymph nodes. Germinal center (GC) reactions in Peyer patches (PPs) lead to generation of α4β7-expressing memory B lymphocytes, which subsequently can differentiate into IgA-secreting plasma cells. Most memory B cells arising in lymph nodes (LNs), on the other hand, differentiate into IgG-secreting plasma cells. These cells express CXCR4 and the integrins α4β1 and LFA-1, which can mediate homing to the bone marrow, where these cells become long-lived plasma cells. The B-cell malignancies related to lymphocyte populations with tissue-specific homing properties are shown in the boxes.