Deletions within WWOX in cases with a t(14;16). (A) Schematic of the WWOX gene located at FRA16D at 16q23. Vertical blue bars indicate exons. The location of the SNPs within the gene on each of the 2 mapping arrays are indicated below the schematic. (B) High-resolution view of the WWOX gene at 16q23. Copy number for each of the 3 t(14;16) samples is indicated below the physical position bar (top). Red dots indicate raw copy number for each SNP. The blue line indicates smoothed copy number. The horizontal bar below each case indicates the presence of normal copy number (yellow) and deletion (green). In all 3 cases, the deletion either commences within WWOX (top case) or lies wholly within WWOX (middle and bottom case), at the presumed translocation breakpoint. The figure was generated using CNAG and the UCSC genome browser.