Figure 1
![Figure 1. mAbTAFI/TM#16 specifically inhibits thrombin-thrombomodulin activation of purified baboon TAFI (bTAFI). (A) In the absence of the mAbTAFI/TM#16, bTAFI is activated by thrombin (IIa) alone, IIa/thrombomodulin (TM)/unfractionated heparin (UH), plasmin (Pn) alone, and Pn/UH, but most effectively by IIa/TM as determined by activity of bTAFIa (inferred from rate of 3-(2-furyl)acryloyl-Ala-Arg-OH [FAAR] hydrolysis). Addition of the mAbTAFI/TM#16 dramatically reduces bTAFIa activity involving TM-associated activation. (B) The same data displayed as percentage inhibition of TAFI activity, illustrating only activation by IIa/TM (± UH) is blocked by the mAbTAFI/TM#16. Data are expressed as mean (± range); n = 2.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/110/9/10.1182_blood-2007-03-078824/7/zh80220708980001.jpeg?Expires=1735540461&Signature=vnCH1oiipx3JXs4Ot7POl8fvDB0TaMG03hl7F1sDMv2QC2VOBK0L1GgTNO8qO0h78h1owA5nqSu8NVBPf-LqbyG1EO1DcBzpYgt2bFpyzyRE3G1XE21gZLYmnkCGnP89hNVvr~pNnEaV9wvUilM5zXuPsF8iPSZFsOH1o~-eZAGqbitxMo~p8OHEYew5LoddyCgfGrJFyeqdDFCxyaTW1cVJE-UKtPuiyb947J4c-ClDPQP9yHPVyh8-nVpcH5Csv6NNvmxzhCg2P0cpotxER05Qmj9778uytWzRQv7xIygDCeU~Bc18xQj0D-n8fJqWz0HJ9LiAtIIOVLpA38WXyQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
mAbTAFI/TM#16 specifically inhibits thrombin-thrombomodulin activation of purified baboon TAFI (bTAFI). (A) In the absence of the mAbTAFI/TM#16, bTAFI is activated by thrombin (IIa) alone, IIa/thrombomodulin (TM)/unfractionated heparin (UH), plasmin (Pn) alone, and Pn/UH, but most effectively by IIa/TM as determined by activity of bTAFIa (inferred from rate of 3-(2-furyl)acryloyl-Ala-Arg-OH [FAAR] hydrolysis). Addition of the mAbTAFI/TM#16 dramatically reduces bTAFIa activity involving TM-associated activation. (B) The same data displayed as percentage inhibition of TAFI activity, illustrating only activation by IIa/TM (± UH) is blocked by the mAbTAFI/TM#16. Data are expressed as mean (± range); n = 2.
