The half-life of mAbTAFI/TM#16 in vivo, measured by antigen and functional activity, is longer than 24 hours. (A) The concentration of mAbTAFI/TM#16, detected by ELISA, dropped rapidly in a control animal within the first hour after infusion, stabilizing during the 24-hour follow-up period (●, left-hand y-axis). Prolongation of clot lysis increased slowly over the 24-hour period, with a maximum of 64 minutes prolongation (49% of T = 0 lysis time) (■, right-hand y-axis). (B) The half-life of the antibody in a baboon model of sepsis, both a sublethal dose of E coli (SLEC) (■) and a lethal dose of E coli (LDEC) (□), is very similar to that seen in the control (●).