Systemic markers of organ damage after P4pal-10 treatment in the Shwartzman reaction. General indication of tissue injury (A; LDH) and organ damage (B-E) in the Shwartzman reaction (t = 6 hours after endotoxin challenge) and the effect of P4pal-10–dependent PAR-4 inhibition. ASAT (B) and ALAT (C) represent liver injury. Creatinine (D) and BUN (E) are markers of renal failure. Total BALF protein (F) is an indicator of permeability of the pulmonary microvasculature. Values are depicted as mean (± SEM). *P < .05, **P < .01.