PAR-4 inhibition, neutrophil influx, and edema formation. Number of neutrophils (Ly6G-positive cells) for 10 microscopic fields (40 ×) in kidney (A) and liver (B) after the induction of the Shwartzman reaction with or without P4pal-10 (0.5 mg/kg) pretreatment. (C) Myeloperoxidase (MPO) activity as a marker of the presence of granulocytes in lung tissue after the induction of the Shwartzman reaction with or without (vehicle) 0.5 mg/kg P4pal-10 pretreatment. (D) Effect of P4pal-10 pretreatment (0.5 mg/kg) on endotoxin-induced pulmonary edema formation as represented by wet-dry ratios. Values are depicted as mean (± SEM). *P < .05