PAR-4 inhibition in neutrophil- and platelet-depleted mice. Effect of P4pal-10 (0.5 mg/kg) pretreatment in mice on injury provoked by the Shwartzman reaction. (A) LDH levels as a general marker for tissue injury. Liver damage as represented by (B) ASAT levels in plasma and (C) BUN as an indicator of renal failure. PMN indicates polymorphonuclear cell. Values are depicted as mean (± SEM). *P < .05