Ki-67 expression by CD38⁺and CD38⁻B cells within individual patients with CLL. PBMCs from 95 patients with CLL and 20 elderly healthy donors were stained as in Figure 1. (A) Dotplots of CD5 and CD38 expression by B cells from 3 patients with CLL and 1 healthy donor. (B) Left panel: Lines connect data points for percentage of Ki-67⁺ cells in CD38⁻ and CD38⁺ subsets within each patients with CLL in the CD38^low subgroup. Note the detection of Ki-67⁺ cells even in the CD38⁻ subset of CD38^low patients (arrow). Right panel: Lines connect data points for percentage of Ki-67⁺ cells in CD38⁻ and CD38⁺ subsets within each CLL clone in the CD38^high subgroup. (C) Lines connect data points for percentage of Ki-67⁺ cells in CD38⁻ and CD38⁺ subsets of all patients with CLL. (D) Left panel: Lines connect data points for percentage of Ki-67⁺ cells in CD38⁻ and CD38⁺ subsets within each healthy participant. Right panel: Same data from left graph drawn to a smaller scale.