The interactions of antileukemic agents with gene products. Antileukemic agents (dashed boxes) interact with gene products typed in this study (genes italicized, with their functions indicated in the colored boxes). Bidirectional arrows indicate that the drugs are both substrates for and competitive inhibitors of the indicated gene products; dashed arrow indicates inductive effect of steroids on CYP3A enzymes; flat-headed arrows indicate inhibitory effects. Genotypes were determined at loci in the indicated genes and analyzed individually; they were also pooled into 1 of 3 major groups: glucocorticoid (green), phase II conjugating (blue), and antimetabolite related (red).