Identification of antithrombin Cambridge II (A384S). (A) PCR-ASRA pattern. (B) Sequence analysis. (C) Pedigree of the family with 5 antithrombin Cambridge II homozygous subjects, with proband identified with an arrow. Type of thrombotic event, age, and recurrence are indicated (NA indicates not available). Filled symbols represent the genetic anomalies identified in this family. (D) Localization of the residue affected by the mutation in the reactive loop (A384S; P10).