SB suppresses LPS-induced systemic secretion of proinflammatory cytokines and lethality in MGRKO mice. (A) Effect of SB (•) or vehicle (▪) on LPS-mediated mortality in MGRKO mice. For the SB-treated group, mice were injected intraperitoneally with SB (2 mg/kg) 1 hour before LPS (10 mg/kg) treatment. P < .01 for SB-treated mice (n = 9) compared with vehicle-treated mice (n = 8). (B) Effect of SB (□) or vehicle (▪) on LPS-mediated induction of TNF-α and IL-6 in MGRKO mice. Mice were injected intraperitoneally with SB or vehicle followed by treatment with LPS for 6 hours. *P < .05 for SB-treated group (n = 5) compared with vehicle-treated group (n = 11). Error bars indicate SEM.