Activation status memory/naive subtypes among CD4 and CD8 T cells in lymph nodes from patients with chronic HIV-1 and patients without HIV-1. Cells were stained for lineage markers, activation (CD38), and memory/naive markers expression on day 1 after surgery. (A-B) Medians (25th-75th percentile) for data obtained with sets of 3 tissue blocks derived from each of 8 patients with chronic HIV-1 and 5 patients without HIV-1. (A) Percentage of cells expressing CD38 among total, naive, effector memory, and central memory CD4 lymphocytes. (B) Percentage of cells expressing CD38 among total, naive, effector memory, and central memory CD8 lymphocytes. Fraction of total T cells expressing CD38 correlated to clinical data from patient CD4 cell count (C) and plasmatic viral load (D). (C) Correlation between the fraction of T cells expressing CD38 at day 1 and the number CD4 T cells. (D) Correlation between the fraction of T cells expressing CD38 at day 1 and the plasmatic viral load. Lines represent linear regressions.