EFS and OS in risk groups defined by the 17-gene model in the test set. The 181 newly diagnosed patients with MM were predicted into high-risk (16.6%) and low-risk (83.4%) groups as described. Kaplan-Meier estimates of survival in low-risk and high-risk myeloma showed 2-year actuarial probabilities of EFS (A) of 88% for the high risk (red) versus 50% for low risk (blue) (P < .001) and OS (B) of 91% for the high-risk (red) versus 54% for the low-risk (blue) (P < .001).