Figure 1
![Figure 1. Ultrastructural morphology of MRP8/MRP14-treated HMECs. Confluent HMEC monolayers treated for 24 hours (A) and 48 hours (B-C) with MRP8/MRP14 were processed for transmission electron microscopy. (A) Ultrastructural analysis reveals signs of apoptosis, such as condensed chromatin (arrows) after 24 hours of treatment. (B) After 48 hours of incubation with MRP8/MRP14, HMECs show alterations of apoptosis (eg, condensed mitochondria [arrows], shrunken nuclei [N], and concomitant necrotic features, such as cytoplasmic vacuolization [V]). (C) Advanced necrotic cell with a pycnotic nucleus (N), swollen mitochondria with amorphous dense bodies (M), and disrupted plasma membrane (arrows). Magnifications, ×2650.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/109/6/10.1182_blood-2006-08-040444/4/zh80060709730001.jpeg?Expires=1735535771&Signature=Ca7lnJVy13yVWRriTl5RezqeaO0V7P4NWtpnoOfE1YUkGZGvSCvPAoAnIi4PJwmMCvA5Ef6sLjKPeYR8utXpB7f-vgyQb9AvHBkcfCd06~d1AmduByjJ41UUVPMQVw-R6FqlpiySvcvVf9t7YK0iwSGU3PpcB5gIGccmahflcffOPI25X1NeS~1VexI1tSeNcAJYGD4IZDPiuJRaEkgoFw6Iyy4-8wKbLiu4-3WXeAtxm8IK8sfI-s8MarjEqrToEwbzFYjiAbRauTA2s0JxQy6ND6RMPcHwJ~fvB~Q2dm-10a3awbq4f-nkNBy9Y7VgCHEfKRGzQhF7kx8nhmxO~g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Ultrastructural morphology of MRP8/MRP14-treated HMECs. Confluent HMEC monolayers treated for 24 hours (A) and 48 hours (B-C) with MRP8/MRP14 were processed for transmission electron microscopy. (A) Ultrastructural analysis reveals signs of apoptosis, such as condensed chromatin (arrows) after 24 hours of treatment. (B) After 48 hours of incubation with MRP8/MRP14, HMECs show alterations of apoptosis (eg, condensed mitochondria [arrows], shrunken nuclei [N], and concomitant necrotic features, such as cytoplasmic vacuolization [V]). (C) Advanced necrotic cell with a pycnotic nucleus (N), swollen mitochondria with amorphous dense bodies (M), and disrupted plasma membrane (arrows). Magnifications, ×2650.
