Figure 2
Figure 2. Effects of anti-RBC immunotherapy, antibody-coated liposomes, and IVIG on RBC counts in mice. MWReg30 was administered by intraperitoneal infusion (0.99 μg/d × 7 days), and treatments were given by bolus injection at 96 hours. RBC counts were obtained using a Cell-Dyn 1700 multiparameter hematology analyzer. (A) Effects of anti-RBC immunotherapy. Symbols represent the sham control group (▾) and animals treated with intravenous injections of saline (•) or TER119 at doses of 5 μg/mouse (▪), 15 μg/mouse (♦), 25 μg/mouse (▴), or 50 μg/mouse (+). Error bars represent the standard deviation associated with the RBC counts. TER119 decreased RBC counts in a dose-dependent manner. Treatment differences were statistically significant (P < .001). (B) Effects of IVIG immunotherapy. Symbols represent the sham control group (▾) and animals treated with intraperitoneal saline (•) or IVIG, administered intraperitoneally, at doses of 0.4 g/kg (▪), 1 g/kg (♦), or 2 g/kg (▴). Error bars represent the standard deviation associated with the RBC counts. RBC counts were not significantly altered (P > .05). (C) Effects of AMI-coated liposomes. Symbols represent the sham control group (▾) and animals treated with intravenous injections of saline (•) or AMI-coated liposomes at doses of 15 μmol/kg (▪), 30 μmol/kg (♦), or 60 μmol/kg (▴). Error bars represent the standard deviation associated with the RBC counts. RBC counts were not significantly altered (P > .05). (D) Effects of IVIG-coated liposomes. Symbols represent the sham control group (▾) and animals treated with intravenous injections of saline (•) or AMI-coated liposomes at doses of 15 μmol/kg (▪), 30 μmol/kg (♦), or 60 μmol/kg (▴). Error bars represent the standard deviation associated with the RBC counts. RBC counts were not significantly altered (P > .05). Please note that all panels include the same sham control group (▾ in each panel) and panels A, C, and D include the same intravenous saline control group (•). Saline was administered intraperitoneally in the saline control group shown in panel B (also symbolized with •).

Effects of anti-RBC immunotherapy, antibody-coated liposomes, and IVIG on RBC counts in mice. MWReg30 was administered by intraperitoneal infusion (0.99 μg/d × 7 days), and treatments were given by bolus injection at 96 hours. RBC counts were obtained using a Cell-Dyn 1700 multiparameter hematology analyzer. (A) Effects of anti-RBC immunotherapy. Symbols represent the sham control group (▾) and animals treated with intravenous injections of saline (•) or TER119 at doses of 5 μg/mouse (▪), 15 μg/mouse (♦), 25 μg/mouse (▴), or 50 μg/mouse (+). Error bars represent the standard deviation associated with the RBC counts. TER119 decreased RBC counts in a dose-dependent manner. Treatment differences were statistically significant (P < .001). (B) Effects of IVIG immunotherapy. Symbols represent the sham control group (▾) and animals treated with intraperitoneal saline (•) or IVIG, administered intraperitoneally, at doses of 0.4 g/kg (▪), 1 g/kg (♦), or 2 g/kg (▴). Error bars represent the standard deviation associated with the RBC counts. RBC counts were not significantly altered (P > .05). (C) Effects of AMI-coated liposomes. Symbols represent the sham control group (▾) and animals treated with intravenous injections of saline (•) or AMI-coated liposomes at doses of 15 μmol/kg (▪), 30 μmol/kg (♦), or 60 μmol/kg (▴). Error bars represent the standard deviation associated with the RBC counts. RBC counts were not significantly altered (P > .05). (D) Effects of IVIG-coated liposomes. Symbols represent the sham control group (▾) and animals treated with intravenous injections of saline (•) or AMI-coated liposomes at doses of 15 μmol/kg (▪), 30 μmol/kg (♦), or 60 μmol/kg (▴). Error bars represent the standard deviation associated with the RBC counts. RBC counts were not significantly altered (P > .05). Please note that all panels include the same sham control group (▾ in each panel) and panels A, C, and D include the same intravenous saline control group (•). Saline was administered intraperitoneally in the saline control group shown in panel B (also symbolized with •).

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