Figure 6
![Figure 6. HK2 is a transcriptional target of LMP1 and is overexpressed in HRS cells. (A) Ectopic expression of LMP1 in L428 cells up-regulated the expression of HK2 (mRNA [left] and protein [right]). (B) Immunohistochemistry was used to study the expression of HK2 in primary HL. (Top) Low-level HK2 expression in germinal center (GC) and mantle zone (MZ) B cells of normal tonsil. (Middle, bottom) Strong staining of HK2 in HRS cells (arrow). Images were acquired using a Zeiss Photomicroscope II (Zeiss UK) equipped with a Nikon Coolpix990 camera and using Corel Paint Shop Pro v.10 software. All images were acquired using a 60 ×/1.4 NA oil-immersion objective lens.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/109/6/10.1182_blood-2006-05-020545/4/zh80060709540006.jpeg?Expires=1735536450&Signature=toQzD-Qb23n0ZrpFs~rOgA-lY0AVCwOwbB07EdGiNQoPsIslYCq2eTxV78uZJWHgdl5OU38Yjr2~lc-u3pgrlINAFXh04i--20YweMAVNqqfHTQQcw4oMSL20IPHkMxz05Z4aytqjQ9VLS3mdgcSqoaE59ms85DrEBOQtKVcADS9pIoBEbEEmHqGhxDjAFcGPplW1QwCRvmSKM5-OxKKV4y~4ZtVKOojNyMIJOK-Z6aQefyphJjPlJSWX2E85zJuUGrtQ7m06rQgiDsK2PJGbAFCV3FDKfEiE47WGFxk1qYIWP89059LbT84S0WVWgCo6tSoYJTwCuoWNnWlHVmi2g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
HK2 is a transcriptional target of LMP1 and is overexpressed in HRS cells. (A) Ectopic expression of LMP1 in L428 cells up-regulated the expression of HK2 (mRNA [left] and protein [right]). (B) Immunohistochemistry was used to study the expression of HK2 in primary HL. (Top) Low-level HK2 expression in germinal center (GC) and mantle zone (MZ) B cells of normal tonsil. (Middle, bottom) Strong staining of HK2 in HRS cells (arrow). Images were acquired using a Zeiss Photomicroscope II (Zeiss UK) equipped with a Nikon Coolpix990 camera and using Corel Paint Shop Pro v.10 software. All images were acquired using a 60 ×/1.4 NA oil-immersion objective lens.
