Liver cirrhosis is associated with reduced PNA binding. (A) PNA binding to VWF was determined in plasma samples of 54 patients diagnosed with liver cirrhosis (“Patients, materials, and methods”). Plotted is relative PNA binding versus VWF antigen levels. The drawn line was obtained by fitting the data in a model describing a single exponential decay (r² = 0.39). (B) Data shown in panel A were subdivided according to Pugh's¹⁸  modification of the Child classification of patients. Data represent the mean of 2 independent determinations, and variance between measurements was 16% or less. Differences between groups were tested with the unpaired 2-tailed t test, with the Welch correction applied when necessary. Bars represent mean values.