Hlx inhibits IFN-γ production by primary CD56^bright NK. PINCO- or PINCO-Hlx–infected primary human NK cells were stimulated for 24 hours with IL-12/IL-18 and were subjected to staining for CD56 and IFN-γ. (left) Infected cells were gated on CD56^brightEGFP⁺ or CD56^dimEGFP⁺. (right) IFN-γ staining in each population compared with isotype controls. Results shown are representative of 3 experiments (CD56^bright PINCO-Hlx compared with CD56^bright PINCO; P < .02).