DKK1-neutralizing antibody promotes bone formation in myelomatous bones. SCID-rab mice engrafted with myeloma cells from 11 patients were treated with anti-DKK1 or control IgG antibody. (A) Changes in BMD (mean ± SEM) of the implanted bones from pretreatment levels. (B) X-ray radiographs of the implanted bones at pretreatment and end of experiment. Note that although BMD in control bones was reduced, anti-DKK1 treatment resulted in increased BMD during the experimental period.