Figure 2
DKK1-neutralizing antibody promotes bone formation in nonmyelomatous bones. SCID-rab mice were engrafted with primary myeloma cells through a direct injection of tumor cells into the implanted rabbit bone (myelomatous hosts)27 or left uninjected (nonmyelomatous hosts). We measured BMD of the experimental SCID-rab mice femur and implanted rabbit bones. (A-B) Changes in BMD (mean ± SEM) of the implanted rabbit bones (A) and mouse femur (B) in nonmyelomatous SCID-rab mice treated with control IgG and anti-DKK1–neutralizing antibody for 4 weeks. (C) Changes in BMD of the uninvolved mouse femur in myelomatous SCID-rab mice treated with control IgG and anti-DKK1 neutralizing antibody.
