Depletion of granules containing granulysin abrogated the anticryptococcal activity of IL-2–activated CD4⁺ T cells from healthy adults. (A) CD4⁺ T cells were activated with IL-2 (+) and treated with SrCl₂ (Sr++). (B) IL-2–activated CD4⁺ T cells were treated with SrCl₂, and the number of C neoformans was determined as indicated. Results are expressed as mean ± SEM. *P < .01 compared with the number of C neoformans alone. Data are representative of 3 independent experiments.